Artemis I is NASA's first mission in the Artemis program that involves sending an uncrewed spacecraft to orbit the Moon with the aim of preparing for future human exploration of the lunar surface. This journey is an exciting yet daunting task that requires years of planning, preparation and training. The spacecraft and the selected astronauts will be faced with an unforgiving space environment that exposes them to radiation, microgravity, extreme temperatures and the unbreathable vacuum of space. In addition, astronauts will perform a range of experiments in this hostile environment. This cluster explores the various aspects of the journey to the Moon including human exposure, the engineering of the spacecraft, the lunar surface and future experiments to be conducted on the Moon.