This text discusses cortical responses; descending pathways; extrapyramidal controls; ventral horn output; and reflexes. Figure 14.27 Phineas Gage The victim of an accident while working on a railroad in 1848, Phineas Gage had a large iron rod impaled through the prefrontal cortex of his frontal lobe. After the accident, his personality appeared to change, but he eventually learned to cope with the trauma and lived as a coach driver even after such a traumatic event. (credit b: John M. Harlow, MD)