Uchungechunge olulodwa lwe-DNA lusetshenziswa njengethempulethi ukudala ikhophi ye-mRNA. Le nqubo ibizwa ngokuthi ukuloba. Ikhophi ye-mRNA idinga ukwenziwa ngoba i-DNA ayikwazi ukushiya i-nucleus. Ingxube yephrotheni yehlukanisa i-DNA helix ukuvumela ukusebenzisana kwe-mRNA nucleotides ukuhlanganisa uchungechunge lwe-DNA. Ukumatanisa kwe-nucleotides kuqonde kahulu. Sebenzisa izinkinobho A, U, G no-C ukubeka i-mRNA nucleotide efanele ne-DNA nucleotide ngayinye.