How to Interpret a Sequence Alignment

How to Interpret a Sequence Alignment

This text introduces how one can interpret biological sequence alignments. An alignment of the human proteins H-RAS, N-RAS, and K-RAS is used as the specific example throughout, but the same general principles hold true for all DNA, RNA, and protein alignments.

Topics

  • sequence
  • alignment
  • conserved
  • conservative
  • semi-conservative
  • non-conservative
  • DNA
  • RNA
  • protein
  • nucleotide
  • amino acid
  • mutation
  • substitution
  • BLOSUM