In Part 1 of this talk, David Baker (U. Washington/HHMI) begins his talk by describing two reciprocal research problems. The first is how to predict the 3-dimensional structure of a protein from a specific amino acid sequence, while the second is how to determine the amino acid sequence that will generate a new protein designed to have a specific structure. Baker’s lab is addressing the second of these challenges by developing computer programs (such as Rosetta@Home) that calculate the lowest energy, or most likely, structures for differently folded amino acid sequences.