Hlola indima yokusebenzisana kwe-hydrophobic ne-hydrophilic ekugoqekeni kwephrotheni. Yenza uchungechunge lwe-peptide olungahleliwe futhi ulibuke indlela eligoqeka ngayo endaweni engamanzi. Shintsha i-solvent ukuze ubone okwenzekayo uma i-peptide isendaweni enguwoyela noma engenalutho yendawo yamanzi.