The Genetics of Drug Metabolism: Clopidogrel
Genetic differences can affect the metabolism of clopidogrel, a drug that prevents blood clots in patients who have a high risk of heart attack or stroke. In this animation, learn how enzymes like CYP2C19 activate clopidogrel, how variations in the CYP2C19 gene can change the effectiveness of the encoded enzyme, and how genetic information can help doctors choose the safest and most effective dosage for each patient.
Topics
- adenosine diphosphate
- ADP
- blood clot
- clopidogrel metabolite
- clopidogrel
- CYP2C19
- cytochrome P450
- DNA
- drug metabolism
- drug metabolite
- enzyme
- genetic information
- genetic variants
- heart attack
- P2Y12 receptor
- pharmacogenetic testing
- platelet aggregation
- platelet
- plavix
- precision medicine
- prodrug
- stroke