The Role of Ubiquitin and the Proteasome (Age 12-15 Years)

Ubiquitin marks proteins for degradation. Learners will understand the ubiquitin-proteasome system's role in protein degradation and its importance in maintaining cellular homeostasis while playing the DEGRADATOR - A Protein Degradation Game. This lesson is designed for learners aged 12-15 years.

Related resources

• Simulation: DEGRADATOR - A Protein Degradation Game
• Reading: Comic on Protein Degradation
• Instructions: Protein Degradation Game Content Description
• Reading: The Great Encyclopedia of Protein Degradation
• Quiz: Test Your Knowledge of Protein Degradation

Topics

• E3 ligase
• PROTAC drugs
• targeted therapies
• protein regulation
• ubiquitin-proteasome system
• enzyme catalysis
• metabolic pathways
• protein turnover
• selective degradation
• homeostasis
• cytoplasm composition
• protein functions
• enzyme structure
• protein degradation