How does systemic racism affect the experiences of racially diverse students in STEM? And why is it important for educators to recognize and address its impact in their classrooms? In this pathway, we’ll explore these questions by examining how racism operates as a system in US society and has become embedded in educational institutions. We’ll also consider how different forms of racism create barriers to learning, which impact the everyday experiences—and often the career paths—of Black, Hispanic, and Indigenous students in STEM. Finally, we’ll introduce strategies that educators and institutions can use to raise awareness of these issues and address them. By confronting the effects of systemic racism in schools, educators and institutions can take an important step toward creating more equitable and inclusive learning environments for all students. This pathway forms part of the Advancing Equity in STEM through Inclusive Teaching cluster. See our equity pledge as part of this initiative.