Does where we are born, live, learn, or play have an impact on our health? Social and environmental determinants of health are factors in our environments, both past and present, that influence our health outcomes and quality of life. Unfortunately, not everyone has the same access to positive social and environmental determinants of health. In the US, systemic racism continues to prevent many Black, Hispanic, and Indigenous communities from accessing educational opportunities, having a stable income, or living in neighborhoods that are free from pollutants. In this pathway, we’ll explore the influence of systemic racism on health outcomes, particularly by understanding the history of residential segregation in the US. Through various case studies, we’ll explore how this history and other forms of discrimination continue to impact the health of racially marginalized groups today. This pathway forms part of the Racism as a Public Health Crisis cluster. See our equity pledge as part of this initiative. Please note: This pathway contains sensitive content related to racial violence and discrimination.